At the turn of the 20th century, cocaine and products containing it were regularly sold at corner pharmacy stores. It was a normal ingredient of tonics, medications, and health products that were popular at the time.¹However, the dangers of cocaine addiction were beginning to present themselves. While many supported or rationalized its use based on stimulant and anesthetic effects, cocaine addiction was a risk to those who used it.

From traditional use by people in the highlands of the Andes Mountains to modern America, public perception of cocaine has traveled a long road.¹ It wasn’t always recognized as an addictive and dangerous substance like it is today, but the history of cocaine points to it being a largely dangerous substance, particularly as its use has evolved over time.

If you or a loved one need treatment for cocaine misuse or addiction, don’t hesitate to contact the caring admissions navigators at American Addiction Centers (AAC). We’re available 24/7 to listen and help you find treatment. Call today at to begin your recovery journey.

About Cocaine

Cocaine is derived from the leaves of the coca plant, Erythroxylum coca. The plant grows naturally only in a select part of the world, northwestern South America.² And even then, not all species of the coca plant contain enough of the cocaine alkaloid (the chemical compound that produces the drug’s effects) to be used as crops for harvesting. Other alkaloids include nicotine, caffeine, and morphine. Viable coca plants are grown primarily in Colombia, Peru, and Bolivia. All three are consistently ranked as the world’s biggest producers, in varying order.

Chewed coca leaves produce stimulant effects that can include feelings of:²

Alertness.
Increased stamina.
Decreased appetite.
Euphoria.

However, the cocaine most today are familiar with is cocaine hydrochloride, the powdered salt of the isolated cocaine alkaloid that is snorted or injected. Cocaine base, also known as crack, is the solid form of cocaine that is smoked.²

Both of these drugs have to go through multiple stages of chemical processing to render the final product — cocaine hydrochloride more so than cocaine base.² Cocaine powder may also be cut with other substances, like fentanyl, that increase the dangers.²

What Are the Effects of Cocaine?

Historically, people have used cocaine because of its stimulative physiological effects that increase energy and sociability, or provide a euphoric high. Cocaine can also act as a local anesthetic, and is used for its effect on the central nervous system.

A numbing sensation is created by inhibiting nerve excitation and blocking conduction. Cocaine also constricts blood vessels, which along with its pain-relieving qualities, are reasons why it is used medically today. Cocaine is a Schedule II drug in the United States, which means it has a higher potential to be misused and can lead to psychological or physical dependence.³

Cocaine’s effect on neurotransmission — which makes it practical in medical settings — is largely responsible for its addictive potential.² Cocaine prevents the natural recycling of dopamine by receptors, and instead allows the chemical to build up and flood the brain.

Continued use will disrupt neural communications in the brain so that it expects excess dopamine and will increasingly reward drug-seeking behaviors. Since cocaine’s effects are short-lived, this compounds the problem, leading people to more frequent use and higher doses of cocaine.²

In terms of cocaine’s effects on the body, there are many acute and chronic conditions, as well as the possibility of fatal overdose.² These may include:²

Paranoia, irritability, restlessness, and aggression.
Hypersensitivity to light, touch, and sounds.
High blood pressure, collapsed veins, and fast or irregular heartbeat.
Nosebleeds as well as deviated septums in the long term.
Diseases and infections transmitted by shared or dirty needles (e.g. HIV and hepatitis).

These risks vary according to the type of use and form of cocaine.

Coca Leaves Used in South America

The coca plant was used often by the populations who were native to Andean regions where it grows. Its use was incorporated into several facets of life, over thousands of years, whether during physical tasks or ceremonies and rituals.

Eventually, coca leaf became a fixture of the Inca empire, which absorbed the separate cultures and assimilated traditional users from different ethnicities and groups. It was used so much that people were observed to have specific tools and containers for coca leaf and lime, which were chewed in tandem to activate the cocaine alkaloid. It was also considered part of religious rituals, and thus subject to various rules governing its use.

Conquistador forces from Spain, however, were among the first non-natives to document traditional coca leaf use. These invaders enslaved native populations as part of their efforts to colonize in the 1500s. At first, the Catholic Church wanted to ban coca leaves. That never happened because colonizers noticed that chewing it contributed to the efficiency of the laborers in the mines and fields.

The church itself went on to create cultivation operations and collect taxes on the plant. The Spanish were even thought to have become coca leaf users themselves, according to an excerpt from Richard J. Miller’s, “Drugged: The science and culture behind psychotropic drugs.”⁴

Coca Gains Popularity in the Victorian Era

It took some time before cocaine became more widely known and used in the Western world. This is in part due to coca leaves not traveling well. Rarely did shipments of coca from the Spanish-controlled Andean regions make it to Europe intact. The potency of the leaves degraded quickly during the time at sea, unlike other commodities such as tea.

It wasn’t until the middle of the 19th century when scientists, doctors, entrepreneurs and others began to take notice of coca leaves and their potential.⁵

In 1863, a chemist from the French island of Corsica starting selling a tonic that was touted for restoring vitality, calming nerves, and bestowing energy. The combination was meant to cover the bitterness of the leaves, but the greater effect was the ethanol of the wine acting as a solvent for the cocaine alkaloid.

Coca use was by that time growing for all sorts of reasons—as a digestive, as a mood enhancer, as a cure for aches and ails—and Vin Mariani soon earned distinguished advocates and a massive following.⁶

The drink, which contained around 6 milligrams of cocaine per ounce, was so acclaimed that Pope Leo XIII officially recognized it with a Vatican medal.⁶ He was far from being the only well-known historical figure with an affection for Vin Mariani — let alone the only pope. Other figures included Queen Victoria of England, Presidents Ulysses Grant and William McKinley, Thomas Edison, as well as the authors Alexandre Dumas, Emila Zola, and Jules Verne.

Chemical Formula of Cocaine Determined

Around the same time as coca gained prominence in Western culture, chemists made rapid scientific progress, fed by better technology and tools. Isolation of alkaloids—like nicotine or morphine—became more efficient and effective.

Chemists before Alfred Niemann had moderate success in extracting cocaine, but the German scientist made the largest steps forward in 1860. Given a cache of coca leaves from South America to investigate for his doctoral thesis, Niemann extracted cocaine in a crystalline form and first sketched out its molecular formula.

The extraction produced a numbing effect when administered to the tongue, Niemann recorded. Alfred Niemann would die the next year, but Wilhelm Lossen, a former student of Niemann’s, would carry on his work and map out a fuller picture of the formula.⁶

The scientific community would have to wait until the close of the century in 1898 for a full understanding of cocaine’s chemical structure was achieved. Richard Willstatter, using knowledge of the tropane alkaloid family to which cocaine belongs, confirmed the structure when he made synthesized cocaine according to the chemical formula he worked out.

Freud, Coca-Cola, and Products Using Cocaine

Before Willstatter had confirmed the structure, Lossen’s elucidation of the cocaine alkaloid would pave the way for the rise of cocaine hydrochloride — the snorted or injected powder that is most commonly associated with drug misuse.

A famous supporter of this form of cocaine, and its overall use, was Sigmund Freud, one of the most influential psychologists in history.⁷ At the time, Freud, a habitual user, would significantly downplay cocaine’s addictive qualities, saying it created “no craving” even after repeated use, but recommended it for several pharmacological applications.⁷His conversations with Karl Koller, a peer and ophthalmologist, would lead the latter to experiment with cocaine as a topical anesthetic.

American advances in cocaine would soon follow, both commercially and medically. A pioneer in U.S. medicine, William Halsted, read about Koller’s success with cocaine and conducted his own trials with the drug as a nerve block for use in surgery.¹

The American version of Vin Mariani would also arrive on the scene in the 1880s: Coca-Cola. The drink was first developed by John Pemberton, who had a morphine addiction, as a wine-based tonic.⁸ Later, a series of tweaks to the recipe in response to Georgia’s outlawing of alcohol led to the carbonated fountain drink consumers today are familiar with.

The beverage as Americans in the late 19th century knew it, however, provided a bit more energy, as it contained cocaine, not caffeine. Like the Bordeaux wine and coca leaves concoction from Mariani, Coca-Cola took off with the public thanks to highly effective marketing.⁸

Soon enough, cocaine was being packaged into home medical kits and sold as a salt in both local drug shops and downtown department stores. Pharmaceutical companies like Merck and Parke-Davis would enter the business of producing and refining cocaine for use, while other patent medicines became staples among Americans.

Cocaine Addiction Rises and Law Enforcement Increases Involvement

Access to cocaine wasn’t very limited and regulation was minimal, allowing thousands of drug-containing products to be made and misused, largely without an understanding of how habit-forming and dangerous cocaine could be.

As America, and the world at large, entered the 1900s, cocaine consumption and addiction rose rapidly. It was estimated there were 200,000 people addicted to cocaine in America in 1902, and coca leaf imports had tripled from 1900 to 1907.⁹

The risks of cocaine misuse became apparent to the public and to some of the influential minds who normalized its use. Halsted did have success with cocaine as an anesthetic, and was a founder of the Johns Hopkins School of Medicine. However, he tested cocaine on himself and developed a severe addiction that ultimately forced him to give up his medical career.⁷

Freud also came to terms with his cocaine addiction, as well as his responsibility for recommending cocaine to countless patients and almost killing one with cocaine-related therapies.⁷ Irregular heartbeats and other reasons lead Freud to renounce his support for cocaine.

By 1903, Coca-Cola had altered its formula drastically and removed cocaine amid increasing pressure, instead of using spent coca leaves that didn’t contain the alkaloid.⁸

By the 1910s, the public and government no longer saw cocaine as a harmless substance, but a dangerous drug. The first attempt to rein in cocaine use and availability had been made in 1906 with the Pure Food and Drugs Act.¹⁰ This act required tonics and other products to list cocaine and other potentially harmful ingredients on their labels.¹⁰

States took action to outlaw its use — a trend that paralleled the growing temperance movement. The Harrison Narcotics Act of 1914 was the first federal law enforcement push targeted at cocaine and other drugs like heroin and morphine.¹¹ It didn’t outright ban the use, but instead limited coca availability to those who got it from a doctor, which functionally restricted the street-level access.

Ultimately, the Jones-Miller Act of 1922 would effectively stamp out rampant cocaine abuse by instituting federal controls over import and export of harmful substances (namely opiates and coca) and by establishing the Federal Narcotics Control Board, essentially convened to eliminate recreational use.¹²

Cocaine Remerges and Crack Cocaine Use Rises

Efforts to limit cocaine misuse succeeded in dampening American enthusiasm for and use of cocaine. While drugs did not disappear entirely, the counterculture that defined the ’60s and early ’70s was more favorable to marijuana, LSD, and other hallucinogens.

Cocaine would reappear, however, amid renewed fame and acclaim. In 1977, Eric Clapton released the song “Cocaine,” extolling its many uses, while 1982 saw the film “Scarface,” which glorified drug trafficking and cocaine abuse, and which is still extremely popular to this day.

Wall Street embraced ’80s excess and cocaine, which was also played up in media and pop culture. Richard Pryor joked about setting himself on fire while trying to freebase cocaine. The cumulative effect was a reemergence of the drug that picked up in the disco era, continued into the club scene of the ’80s, and beyond.

It also seemingly amounted to a collective public forgetting of the very real dangers of cocaine. Deaths due to cocaine abuse quadrupled between 1976 and 1981.¹³ Despite this alarming number, 1983 saw 10.4 million people try cocaine for the first time, marking the peak of American use.

Cocaine was, and is, a more expensive drug than crack cocaine.¹⁴ Crack cocaine was invented as a cheaper and safer alternative to freebasing, which amplified both the psychostimulant effects and addictive potential.¹⁴ Crack, which is powdered cocaine cooked with water and baking soda to form cocaine base, allowed drug dealers to stretch their supply — but the result was an inner-city crisis that has had long-term socioeconomic effects.

Crack cocaine use became prevalent in major urban areas like New York City, Los Angeles, Detroit, Chicago, Houston, Atlanta, and Miami. The low price and amount available caused crack misuse that led to addiction and crime that destroyed lives and communities. By 1985, there were more than 12 million cocaine users in America, with around a quarter of a million using daily.¹⁵

Cocaine in America Today

While cocaine and crack remain among the most dangerous drugs, their use has retreated once again. According to the 2022 National Survey on Drug Use and Health, around 5.3 million people in America (people aged 12 or older) had used cocaine in the past year; 918,000 had used crack during that same time.¹⁶The adulteration of cocaine with fentanyl and other substances is a major contributor to the increase in drug overdose deaths.²

Find Help for Cocaine Misuse and Addiction

The history of cocaine is a long one, and the issues of misuse and addiction that the U.S. and the world experience are extensive. If you or a loved one need treatment for cocaine misuse or addiction, don’t hesitate to contact the caring admissions navigators at American Addiction Centers (AAC).

We’re available 24/7 to listen, help you find treatment, and check your insurance coverage. Call today at to begin your recovery journey.

The History of Cocaine Around the World and in the United States