Opioid Withdrawal: Timeline, Symptoms & Treatment

What Is Opioid Withdrawal?

Opiates (morphine, codeine) are naturally occurring drugs taken directly from the opium plant. They are prescribed to treat pain conditions, but they are also addictive.

Tolerance and dependence develop rapidly in those who abuse opiates – and even in those who use them as prescribed.1,2 If a person becomes dependent on opiates and stops using them, they will experience a range of withdrawal symptoms that may be painful, but not necessarily life-threatening. 1,3


Opiate Withdrawal Symptoms can range from mild to severe.

Some of the common opiate withdrawal signs and symptoms include the following:1,2,3,4

  • Watery eyes
  • Runny nose
  • Yawning
  • Sweating
  • Hot and cold flashes
  • Dilated pupils
  • Chills or gooseflesh
  • Loss of appetite
  • Restlessness
  • Agitation
  • Anxiety
  • Tremors
  • Abdominal cramps
  • Nausea
  • Vomiting
  • Fever
  • Muscle aches and pains
  • Increased blood pressure and/or heart rate
  • Insomnia or other sleep problems

Several factors will affect the severity of opiate withdrawal as well as the length of time it takes to detox from opiates. These factors include:2,4,5
  • How long a person has been dependent on opiates.
  • The type of opiate the person is dependent on.
  • The frequency and severity of opiate abuse.

Opioid Withdrawal Complications

Complications associated with opiate withdrawal include:3

  • Aspiration, or accidentally inhaling stomach contents into the lungs, which can lead to lung infection and asphyxiation.
  • Severe dehydration caused by lack of fluid replacement after sweating, vomiting, and diarrhea.
  • Suicidal thoughts, which some people experience in association with severe withdrawal symptoms.
  • Relapse due to a desire to relieve withdrawal symptoms. Relapse can prove fatal if a person’s tolerance significantly decreases during abstinence. The risk of unintentional overdose increases if the person returns to using the amount he or she was accustomed to.3

Opioid Detox Timeline

If a person is dependent on an opiate and abruptly stops using it, they will experience withdrawal symptoms within a few hours.

These symptoms will usually peak within 48-72 hours and subside within a period of 10 days, though some users may continue to experience symptoms for weeks or months.5,6 The onset, duration, and intensity of withdrawal symptoms will be different for each person.

The general opiate withdrawal timeline includes the following: 2,5

  • 8-12 hours. Anxiety, agitation, watery eyes, runny nose, and increased sweating.
  • 12-24 hours. Nausea, stomach cramps, vomiting, diarrhea, goose bumps, and dilated pupuils.
  • 36-72 hours. Symptoms peak and then gradually subside over the next few days.

Causes of Withdrawal

Withdrawal from opiates is a result of neuroadaptation, a process in which the body adjusts to the presence of opiates, leading to tolerance and dependence.

Tolerance occurs when opioid receptors in the brain begin to resist the drug. As a result, the user experiences less of a response from the drug over time. Tolerance often drives opiate users to take higher doses to achieve the same effect as before.1

Dependence occurs when the body begins to rely on opiates to function properly. A person who has become dependent on opiates will very likely experience withdrawal symptoms if and when they stop use of the drug.1,2

Dependence and addiction are not the same thing. A person who takes opiates for an extended period of time will most likely become physiologically dependent. However, they may not display the compulsive behavioral seen in addiction. A person who is addicted to opiates has a strong urge, desire, or craving for opiates that is difficult to control. 1

Treatment for Withdrawal

Treatment for opiate dependence typically begins with detoxification from the drug followed by either 28-or 30-day, 60-day or 90-day inpatient treatment or some form of structured outpatient treatment (partial hospitalization or intensive outpatient programs).

A medically supervised treatment facility can provide a stable, comfortable environment in which to detox, while providing support and medications to help reduce the likelihood of complications. Detoxing at a medically supervised facility can also greatly minimize the severity of the symptoms and make the withdrawal process easier to tolerate.

Treatment options for opiate withdrawal and addiction include:

  • Detox Opiate detox centers provide around-the-clock medical care for withdrawal symptoms and ensure a safe and comfortable withdrawal process. Detox typically lasts anywhere from several days to a week.1
  • InpatientInpatient opiate facilities also provide around-the-clock care. But the main focus is on recovering from an addiction to or dependence on opiates. These facilities provide individual, family, group, nutritional, and recreational therapy and will work with you to create an aftercare plan.
  • Partial hospitalization program (PHP)PHPs provide group therapy and medication management of psychiatric symptoms. At times, these programs will also include brief individual sessions and weekly family sessions. It is important to find a substance-specific PHP as many of these programs are for mental health.
  • Intensive outpatient program (IOP)IOPs provide group and individual therapy. You must visit a psychiatrist outside the program for medication management. The services are similar to those at a PHP.


Opiate relapse is common, and maintaining some form of long-term treatment or aftercare is important.1,3 These options include psychiatric care, individual therapy, group therapy, and 12-step groups, among others.

  • Psychiatric care – Finding a psychiatrist who listens to you and treats your psychological symptoms can help you maintain recovery. Depression, anxiety, and sleep problems are common for those recovering from opiate dependence. A psychiatrist can prescribe medications for these conditions. If you were prescribed opiates for pain relief, you may also want to see a primary care provider to find other ways to treat pain.
  • Individual therapyAn individual therapist can help you work through the issues that may have driven your opiate dependence. They can also help you discover healthier ways to cope with stress and help you learn to live without opiates.
  • Group therapy Group therapy can offer ongoing support during recovery. You meet with other people who are recovering from substance abuse, while a therapist leads a group on different recovery topics, including relapse prevention and addiction education.
  • 12-step and non-12-step support programs Some options that are helpful to those with opiate dependence and addiction include SMART Recovery and Narcotics Anonymous.3 Support groups provide education, feedback, and a mentor or sponsor to help you complete recovery steps.
  • Sober living homes – Also known as halfway houses, these programs offer temporary housing for people recovering from opiate abuse. Residents attend 12-step meetings or therapy sessions, look for work or housing, and receive support as they transition back into their communities.


Physicians may use medications during opiate withdrawal treatment. These medications make the withdrawal process less painful and help a person maintain sobriety. The medications include, but may not be limited to, the following:1,3,4

  • Buprenorphine can decrease the length of time it takes to detox from opiates and help a person maintain long-term abstinence from opiates. A person who is prescribed buprenorphine may eventually be tapered off the medication.
  • Methadone can help relieve or lessen withdrawal symptomsand can also be used as a long-term maintenance therapy for opiate-dependent individuals. Methadone must be dispensed on-site at approved clinics and may eventually be tapered and quit completely under supervision.
  • Naltrexone blocks the effects of opiates and may be used to induce withdrawal. It may also be used to prevent future dependence and misuse.
  • Clonidine can help relieve the flu-like symptoms associated with withdrawal as well as the anxiety and agitation some experience.
  • Other medications may be used for symptoms such as stomach cramps, diarrhea, insomnia, anxiety, and depression.

The medications described above will be used at the discretion of the attending physician. Asking which types of medications a facility uses for opiate detox will give you a clearer idea of the treatment course the center prefers.

Find a Detox Center

If you or a loved one is dealing with dependence or addiction to opiates, contact one of our treatment support representatives at to find the best treatment option for you.

Substance-Specific Helpful Information

[1]. Harvard Medical School. (2009). Treating opiate addiction, part I: Detoxification and maintenance.

[2]. Eddy, N. B., Halbach, H., Isbell, H., & Seevers, M. H. (1965). Drug dependence: its significance and characteristics. Bulletin of the World Health Organization, 32(5), 721-733.

[3]. U.S. National Library of Medicine. (2013). Medline Plus, Opiate Withdrawal.

[4]. Wesson, D. R., & Ling, W. (2003). The clinical opiate withdrawal scale (COWS). Journal of psychoactive drugs, 35(2), 253-259.

[5]. Farrell, M. (1994). Opiate withdrawal. Addiction 89(1):1471-1475.

[6]. Substance Abuse and Mental Health Services. (2010). Protracted Withdrawal.