Learn More About Polysubstance Use
Mixing Alcohol With Other Substances
Other Polysubstance Use Combinations
Polysubstance Use: What Is Polysubstance Use?
Polysubstance occurs when a person uses two or more substances (drugs and/or alcohol) at the same time or in quick succession—intentionally or unintentionally.1 Whether intentional or unintentional, the use of multiple substances is never safe and can lead to dangerous and unpredictable effects.1
What Is Polysubstance Use?
Polysubstance use refers to the use of two or more substances at the same time or within a short period.1 Examples of polysubstance use include using alcohol and prescription opioids or using cocaine and heroin together (speedballing).1 This can happen intentionally or unintentionally, but it is never safe even when done on purpose. Mixing multiple drugs or mixing drugs and alcohol can make the effects of each substance stronger and more unpredictable than using them alone.1
Dangers of Polysubstance Use
There are many dangers of mixing drugs. Polysubstance can cause a range of adverse health effects depending on the combination of substances involved.2 Potential adverse health effects may include:2
- Brain damage.
- Psychiatric illnesses (e.g., psychosis).
- Seizures.
- Respiratory failure.
- Heart issues.
- Liver damage or liver failure.
- Bleeding in the stomach.
- Heatstroke.
- Coma.
Dangers of Specific Substance Combinations
Polysubstance Use & Addiction
People who use one substance often use another, which can put them at greater risk of developing a substance use disorder (SUD), also referred to as addiction.2 An SUD is a condition in which a person compulsively uses a substance despite the physical, psychological, and social problems use causes.2
Many people discover that once they begin using multiple substances, it is difficult to stop.2 Once a single SUD develops, a person is at an increased risk of developing dependence on additional substances.4
Treatment for Polysubstance Use
If you or a loved one are struggling with polysubstance use, know that treatment is available, and can help address the use of multiple substances.
Treating polysubstance use can be complex and requires a comprehensive approach that addresses the use of multiple substances as well as potential withdrawal symptoms from multiple substances.2 Many individuals who struggle with polysubstance use also have medical, psychiatric, and social needs that must be considered.2 Effective treatment for polysubstance use is individualized and balances these challenges while providing integrated support.2
Getting Help for Polysubstance Use Addiction
If you or a loved one are struggling with polysubstance use or polysubstance use disorders, treatment is waiting for you. You can take the next step and find rehabs near you using our search tool. Search by insurance provider, level of addiction treatment, location, and more.
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